Sample Size

Sample Size Considerations for Microbial Metagenomics Research

One of the most common questions we get from investigators at the Microbial Metagenomics Analysis Center (MMAC) is how many samples should I collect for my study? Even once we have a clearly stated and testable hypothesis, this is not always easy, since sample size calculations for microbiome studies are typically not amenable to closed form solutions (i.

Sample Size Considerations for Microbiome One-at-a-Time Differential Abundance Testing

I was recently asked how many samples we might need to formally power a differential abundance analysis of prevalent species in the human stool microbiome between “otherwise healthy” control samples and patients with a specific disease condition.